Brigatinib Intermediates CAS 1197953-49-3

AP26113 Intermediate 5 CAS number is 1197953-49-3. it is an important intermediate for the synthesis of AP26113. We found the relevant information in the literature reported its synthetic route, roughly use 2,4,5-trichloropyrimidine and 2- (dimethyl oxophosphonium) aniline as the raw material to replace the reaction to produce the target compound. Although the synthesis of this route is relatively simple, but there are three chlorine atoms on 2,4,5-trichloropyrimidine has little difference on the nucleophilic activity,when in the face of the same or similar aniline groups, the location of selectively will inevitably produce interference, resulting in unnecessary side effects, thus affecting the quality of the product. At the same time, the use of precious metal palladium reagents during the reaction also increases the manufacturing cost and is not conducive to its industrialization. Thera. Category: Anti-cancer Cas No.:1197953-54-0 Synonyms: AP26113 Intermediate 1;2,5…