1-(2-Fluoro-6-trifluoromethyl-benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione For Elagolix Sodium 830346-47-9

Elagolix Sodium intermediate has the chemical name of 1-(2-Fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS number is 830346-47-9, The molecular formula is C13H10F4N2O2, it has a molecular weight of 302.22. His synthesis was carried out by adding 100 mol of 5-bromo-6-methylpyrimidine-2,4(1H,3H)-dione and 100 mol of 2-(bromomethyl)-1-fluoro-3-trifluoromethyl to a three-necked flask. Base benzene and 103 mL of N,N-dimethylformamide were stirred and dissolved, and then 200 mol of potassium carbonate was added thereto, and the mixture was stirred and heated to 75 to 85 ℃ overnight. At the end of the reaction, 205 mL of water was added to precipitate a large amount of solid, which was filtered and dried to obtain 30.88 g of Elagolix Sodium intermediate1-(2-Fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS number 830346-47-9, potassium carbonate may be replaced by sodium carbonate, cesium carbonate or potassium t-butoxide. The solvent N,N-…